Underwriter

Biotech company (symbol)

Date priced

Offering price per share

12/31/13 share price

Offering gross (M)

After-market
performance
(+/-%)


Aegis Capital

Aastrom Biosciences Inc.3 (Ann Arbor, Mich.; ASTM) (co-lead)

8/14/13

$6.00

$3.23

$8.70

-46%

Aegis Capital

Advaxis Inc. (Princeton, N.J.; OTCQB:ADXS)

10/17/13

$4.00

$4.24

$26.50

6%

Aegis Capital

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (co-lead)

10/25/13

$16.50

$18.00

$37.95

9%

Aegis Capital

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (lead) (IPO)

5/22/13

$8.00

$18.00

$25.00

125%

Aegis Capital

Cytrx Corp. (Los Angeles; CYTR) (lead)

10/10/13

$2.25

$6.27

$25.90

179%

Aegis Capital

Evoke Pharma Inc. (San Diego; EVOK) (IPO) (lead)

9/25/13

$12.00

$7.45

$28.98

-38%

Aegis Capital

Heat Biologics (Chapel Hill, N.C.; HTBX) (lead) (IPO)

7/24/13

$10.00

$7.10

$25.00

-29%

Aegis Capital

Imprimis Pharmaceuticals Inc. (Solana Beach, Calif.; IMMY) (co-lead)

2/11/13

$5.25

$3.36

$9.66

-36%

Aegis Capital

Neostem Inc. (New York; NBS) (lead)

10/4/13

$7.00

$6.82

$40.25

-3%

Aegis Capital

Neostem Inc.4 (New York; NYSE:NBS) (lead)

4/30/13

$5.00

$6.82

$10.75

36%

Aegis Capital

Oculus Innovative Sciences Inc.5 (Petaluma, Calif.; OCLS) (lead)

3/7/13

$2.80

$3.48

$3.45

24%

Aegis Capital

Opexa Therapeutics Inc. (The Woodlands, Texas; OPXA) (lead)

8/8/13

$1.50

$1.82

$18.98

21%

Aegis Capital

Opexa Therapeutics Inc. (The Woodlands, Texas; OPXA) (lead)

12/18/13

$1.70

$1.82

$7.00

7%

Aegis Capital

Sorrento Therapeutics Inc. (San Diego; SRNE) (lead)

10/28/13

$7.25

$8.10

$34.58

12%

Aegis Capital

Stemline Therapeutics Inc. (New York; STML) (lead) (IPO)

1/29/13

$10.00

$19.60

$38.20

96%

Aegis Capital

Synthetic Biologics Inc. (Rockville, Md.; NYSE:SYN) (lead)

12/13/13

$1.00

$1.53

$13.23

53%

Ascendiant Capital

Repros Therapeutics Inc. (The Woodlands, Texas; RPRX)

6/20/13

$19.00

$18.30

$81.94

-4%

Baird

Ambit Biosciences Inc. (San Diego; AMBI) (IPO)

5/16/13

$8.00

$9.64

$65.00

21%

Baird

Cerus Corp. (Concord, Calif.; CERS)

3/14/13

$4.20

$6.45

$35.00

54%

Baird

Tesaro Inc. (Waltham, Mass.; TSRO)

3/1/13

$18.00

$28.24

$97.20

57%

Baird

Trius Therapeutics Inc.7 (San Diego; TSRX) (co-lead)

1/18/13

$4.75

$13.63

$34.20

187%

Bank of America Merrill Lynch

Bluebird Bio Inc. (Cambridge, Mass.; BLUE) (co-lead) (IPO)

6/19/13

$17.00

$20.98

$116.11

23%

Bank of America Merrill Lynch

Durata Therapeutics Inc. (Chicago; DRTX) (co-lead)

4/12/13

$7.00

$12.79

$50.05

83%

Bank of America Merrill Lynch

Intercept Pharmaceuticals Inc. (New York; ICPT) (co-lead)

6/19/13

$33.01

$68.28

$65.69

107%

Bank of America Merrill Lynch

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD) (co-lead)

5/22/13

$13.00

$11.61

$145.60

-11%

Bank of America Merrill Lynch

Karyopharm Therapeutics Inc. (Natick, Mass.; KPTI) (co-lead) (IPO)

11/7/13

$16.00

$22.92

$125.12

43%

Bank of America Merrill Lynch

Kythera Biopharmaceuticals Inc. (Calabasas, Calif.; KYTH) (co-lead)

10/9/13

$45.75

$37.35

$120.00

-18%

Bank of America Merrill Lynch

Macrogenics Inc. (Rockville, Md.; MGNX) (co-lead) (IPO)

10/11/13

$16.00

$27.43

$92.00

71%

Bank of America Merrill Lynch

Omthera Pharmaceuticals Inc.2 (Princeton, N.J.; OMTH) (co-lead) (IPO)

4/12/13

$8.00

$12.70

$64.00

59%

Bank of America Merrill Lynch

Onyx Pharmaceuticals Inc.8 (South San Francisco; ONXX) (co-lead)

1/16/13

$81.50

$125.00

$358.60

53%

Bank of America Merrill Lynch

Prothena Corp. plc (Dublin; PRTA) (co-lead)

10/13/13

$22.00

$26.52

$77.00

21%

Bank of America Merrill Lynch

Relypsa Inc. (Redwood City, Calif.; RLYP) (co-lead) (IPO)

11/15/13

$11.00

$25.00

$85.80

127%

Bank of America Merrill Lynch

Repros Therapeutics Inc. (The Woodlands, Texas; RPRX) (lead)

6/20/13

$19.00

$18.30

$81.94

-4%

Bank of America Merrill Lynch

Sagent Pharmaceuticals Inc. (Schaumburg, Ill.; SGNT) (co-lead)

9/11/13

$21.25

$25.38

$75.28

19%

Barclays Capital

Cempra Inc. (Chapel Hill, N.C.; CEMP) (co-lead)

6/14/13

$7.00

$12.39

$57.75

77%

Barclays Capital

Fibrocell Science Inc. (Exton, Pa.; FCSC) (co-lead)

9/26/13

$4.10

$4.06

$50.43

-1%

Barclays Capital

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Barclays Capital

Omthera Pharmaceuticals Inc.2 (Princeton, N.J.; OMTH) (co-lead) (IPO)

4/12/13

$8.00

$12.70

$64.00

59%

Barclays Capital

Onyx Pharmaceuticals Inc.8 (South San Francisco; ONXX) (co-lead)

1/16/13

$81.50

$125.00

$358.60

53%

Barclays Capital

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH) (co-lead) (IPO)

3/20/13

$7.00

$13.52

$80.58

93%

BMO Capital

Ambit Biosciences Inc. (San Diego; AMBI) (IPO)

5/16/13

$8.00

$9.64

$65.00

21%

BMO Capital

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA)

1/24/13

$19.60

$6.82

$323.40

-65%

BMO Capital

Fate Therapeutics Inc. (San Diego; FATE) (co-lead) (IPO)

10/1/13

$6.00

$6.28

$46.20

5%

BMO Capital

Five Prime Therapeutics Inc. (South San Francisco; FPRX) (co-lead) (IPO)

9/18/13

$13.00

$16.79

$71.80

29%

BMO Capital

Intercept Pharmaceuticals Inc. (New York; ICPT) (co-lead)

6/19/13

$33.01

$68.28

$65.69

107%

BMO Capital

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS)

5/9/13

$19.00

$39.84

$182.70

110%

BMO Capital

Oncomed Pharmaceuticals Inc. (Redwood City, Calif.; OMED) (IPO)

7/18/13

$17.00

$29.52

$93.50

74%

BMO Capital

Receptos Inc. (San Diego; RCPT) (co-lead) (IPO)

5/9/13

$14.00

$28.99

$72.80

107%

BMO Capital

Regado Biosciences Inc. (Basking Ridge, N.J.; RGDO) (co-lead) (IPO)

8/22/13

$4.00

$4.77

$46.68

19%

BMO Capital

Regulus Therapeutics Inc. (La Jolla, Calif.; RGLS) (co-lead)

7/17/13

$9.50

$7.39

$49.20

-22%

BMO Capital

Tesaro Inc. (Waltham, Mass.; TSRO)

3/1/13

$18.00

$28.24

$97.20

57%

BMO Capital

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH) (co-lead) (IPO)

3/20/13

$7.00

$13.52

$80.58

93%

BMO Capital

Tetraphase Pharmaceuticals Inc. (Watertown, Mass; TTPH) (co-lead)

11/4/13

$10.00

$13.52

$49.00

35%

Brean Capital

A.P. Pharma Inc. (Redwood City, Calif.; OTCBB:APPA)

11/21/13

$0.40

$0.45

$60.00

13%

Brean Capital

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Brean Capital

Celldex Therapeutics Inc. (Needham, Mass.; CLDX)

2/6/13

$7.50

$24.21

$103.50

223%

Brean Capital

Inovio Pharmaceuticals Inc. (Blue Bell, Pa.; NYSE:INO)

3/7/13

$0.55

$2.90

$15.06

427%

Brean Capital

Intellipharmaceutics International Inc. (Toronto; IPCI)

8/1/13

$2.05

$3.71

$3.10

81%

Brean Capital

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Brean Capital

Progenics Pharmaceuticals Inc. (Tarrytown, N.Y.; PGNX)

6/21/13

$4.40

$5.33

$37.40

21%

Brean Capital

Synta Pharmaceuticals Corp. (Lexington, Mass.; SNTA)

11/14/13

$3.75

$5.24

$60.38

40%

Brean Capital

TG Therapeutics Inc. (New York; TGTX) (co-lead)

7/18/13

$6.15

$3.90

$35.10

-37%

Burrill Securities

Novavax Inc. (Rockville, Md.; NVAX)

9/24/13

$3.14

$5.12

$99.85

63%

Burrill Securities

Novelos Therapeutics Inc. (Madison, Wis.; NVLT) (co-lead)

2/14/13

$0.50

$0.37

$5.50

-26%

C&Co./Princeridge

Rockwell Medical Inc. (Wixom, Mich.; RMTI)

5/15/13

$3.05

$10.44

$40.30

242%

Canaccord Genuity

Aegerion Pharmaceuticals Inc. (Cambridge, Mass.; AEGR)

1/14/13

$26.64

$70.96

$72.05

166%

Canaccord Genuity

Aerie Pharmaceuticals Inc. (Bedminster, N.J.; AERI) (IPO)

10/28/13

$10.00

$17.96

$77.20

80%

Canaccord Genuity

Aeterna Zentaris Inc. (Quebec City; AEZS) (lead)

11/20/13

$1.15

$1.38

$15.00

20%

Canaccord Genuity

Anacor Pharmaceuticals Inc. (Palo Alto, Calif.; ANAC)

4/26/13

$6.39

$16.78

$23.00

163%

Canaccord Genuity

Aveo Oncology Inc. (Cambridge, Mass.; AVEO)

1/17/13

$7.50

$1.83

$57.75

-76%

Canaccord Genuity

Bluebird Bio Inc. (Cambridge, Mass.; BLUE) (IPO)

6/19/13

$17.00

$20.98

$116.11

23%

Canaccord Genuity

GW Pharma plc (Wilshire, UK; GWPH) (IPO)

5/1/13

$8.90

$41.54

$31.15

367%

Canaccord Genuity

Insmed Inc. (Monmouth Junction, N.J.; INSM)

7/17/13

$10.40

$17.00

$62.40

63%

Canaccord Genuity

Intermune Inc. (Brisbane, Calif.; ITMN)

1/16/13

$9.90

$14.73

$133.65

49%

Canaccord Genuity

Mast Therapeutics Inc. (San Diego; MSTX) (co-lead)

6/14/13

$0.50

$0.46

$25.00

-8%

Canaccord Genuity

Mimedx Group Inc. (Marietta, Ga.; MDXG) (co-lead)

12/12/13

$6.80

$8.74

$34.00

29%

Canaccord Genuity

Newlink Genetics Corp. (Ames, Iowa; NLNK)

1/31/13

$11.40

$22.01

$52.44

93%

Canaccord Genuity

NPS Pharmaceuticals Inc. (Bedminster, N.J.; NPSP)

5/20/13

$14.53

$30.36

$100.26

109%

Canaccord Genuity

Regado Biosciences Inc. (Basking Ridge, N.J.; RGDO) (IPO)

8/22/13

$4.00

$4.77

$46.68

19%

Canaccord Genuity

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

9/25/13

$56.63

$64.72

$178.95

14%

Canaccord Genuity

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

1/3/13

$47.53

$64.72

$118.83

36%

Canaccord Genuity

Synergy Pharmaceuticals Inc. (New York; SGYP)

4/9/13

$5.50

$5.63

$90.00

2%

Canaccord Genuity

Xoma Corp. (Berkeley, Calif.; XOMA) (co-lead)

8/20/13

$3.62

$6.73

$31.50

86%

Cantor Fitzgerald

Apricus Biosciences Inc. (San Diego; APRI)

5/24/13

$2.85

$2.65

$17.10

-7%

Cantor Fitzgerald

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Cantor Fitzgerald

Evoke Pharma Inc. (San Diego; EVOK) (IPO)

9/25/13

$12.00

$7.45

$28.98

-38%

Cantor Fitzgerald

Heat Biologics (Chapel Hill, N.C.; HTBX) (IPO)

7/24/13

$10.00

$7.10

$25.00

-29%

Cantor Fitzgerald

Newlink Genetics Corp. (Ames, Iowa; NLNK)

1/31/13

$11.40

$22.01

$52.44

93%

Cantor Fitzgerald

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

Chardan Capital Markets

Cel-Sci Corp. (Vienna, Va.; NYSE Amex:CVM) (co-lead)

10/9/13

$1.00

$0.59

$17.80

-41%

Chardan Capital Markets

Rockwell Medical Inc. (Wixom, Mich.; RMTI) (lead)

5/15/13

$3.05

$10.44

$40.30

242%

Chardan Capital Markets

Stemcells Inc. (Newark, Calif.; STEM) (co-lead)

10/2/13

$1.45

$1.23

$18.63

-15%

Citigroup

Acceleron Pharma Inc. (Cambridge, Mass.; XLRN) (co-lead) (IPO)

9/19/13

$15.00

$39.60

$96.26

164%

Citigroup

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN) (co-lead)

3/1/13

$8.40

$3.32

$141.96

-60%

Citigroup

Amarin Corp. plc (Dublin; AMRN) (co-lead)

7/10/13

$5.60

$1.97

$121.52

-65%

Citigroup

Ambit Biosciences Inc. (San Diego; AMBI) (co-lead) (IPO)

5/16/13

$8.00

$9.64

$65.00

21%

Citigroup

Epizyme Inc. (Cambridge, Mass.; EPZM) (co-lead) (IPO)

5/31/13

$15.00

$20.80

$88.70

39%

Citigroup

Esperion Therapeutics Inc. (Plymouth, Mich.; ESPR) (co-lead) (IPO)

6/26/13

$14.00

$13.74

$80.50

-2%

Citigroup

Intercept Pharmaceuticals Inc. (New York; ICPT) (co-lead)

6/19/13

$33.01

$68.28

$65.69

107%

Citigroup

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Citigroup

Onconova Therapeutics Inc. (Newtown, Pa.; ONTX) (co-lead) (IPO)

7/25/13

$15.00

$11.48

$88.50

-23%

Citigroup

Prosensa Holding BV (Leiden, the Netherlands; RNA) (co-lead) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

Citigroup

Sophiris Bio Inc. (San Diego; SPHS) (co-lead) (IPO)

8/16/13

$5.00

$3.70

$65.00

-26%

Citigroup

Synergy Pharmaceuticals Inc. (New York; SGYP)

4/9/13

$5.50

$5.63

$90.00

2%

Citigroup

Tesaro Inc. (Waltham, Mass.; TSRO) (co-lead)

3/1/13

$18.00

$28.24

$97.20

57%

Citigroup

Trius Therapeutics Inc.7 (San Diego; TSRX) (co-lead)

1/18/13

$4.75

$13.63

$34.20

187%

Cowen & Co.

Acadia Pharmaceuticals Inc. (San Diego; ACAD) (co-lead)

5/15/13

$12.50

$24.99

$115.00

100%

Cowen & Co.

Aegerion Pharmaceuticals Inc. (Cambridge, Mass.; AEGR)

1/14/13

$26.64

$70.96

$72.05

166%

Cowen & Co.

Bind Therapeutics Inc. (Cambridge, Mass.; BIND) (co-lead) (IPO)

9/20/13

$15.00

$15.09

$70.50

1%

Cowen & Co.

Dyax Corp. (Burlington, Mass.; DYAX)

10/10/13

$6.50

$7.54

$60.00

16%

Cowen & Co.

Dynavax Technologies Corp. (Berkeley, Calif.; DVAX) (lead)

10/25/13

$1.08

$1.96

$132.20

82%

Cowen & Co.

Kythera Biopharmaceuticals Inc. (Calabasas, Calif.; KYTH)

10/9/13

$45.75

$37.35

$120.00

-18%

Cowen & Co.

Mei Pharma Inc. (San Diego; MEIP) (co-lead)

10/28/13

$8.00

$8.01

$35.00

0%

Cowen & Co.

Portola Pharmaceuticals Inc. (South San Francisco; PTLA)

10/17/13

$23.75

$25.75

$105.90

8%

Cowen & Co.

Regado Biosciences Inc. (Basking Ridge, N.J.; RGDO) (co-lead) (IPO)

8/22/13

$4.00

$4.77

$46.68

19%

Cowen & Co.

Relypsa Inc. (Redwood City, Calif.; RLYP) (IPO)

11/15/13

$11.00

$25.00

$85.80

127%

Cowen & Co.

Sangamo Biosciences Inc. (Richmond, Calif.; SGMO)

9/19/13

$10.58

$13.89

$74.22

31%

Cowen & Co.

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

9/25/13

$56.63

$64.72

$178.95

14%

Cowen & Co.

Xoma Corp. (Berkeley, Calif.; XOMA) (co-lead)

8/20/13

$3.62

$6.73

$31.50

86%

Cowen & Co.

Agios Pharmaceuticals Inc. (Cambridge, Mass.; AGIO) (IPO)

7/24/13

$18.00

$23.95

$120.60

33%

Cowen & Co.

Anacor Pharmaceuticals Inc. (Palo Alto, Calif.; ANAC) (lead)

4/26/13

$6.39

$16.78

$23.00

163%

Cowen & Co.

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA) (co-lead)

1/24/13

$19.60

$6.82

$323.40

-65%

Cowen & Co.

Bluebird Bio Inc. (Cambridge, Mass.; BLUE) (IPO)

6/19/13

$17.00

$20.98

$116.11

23%

Cowen & Co.

Cempra Inc. (Chapel Hill, N.C.; CEMP) (co-lead)

6/14/13

$7.00

$12.39

$57.75

77%

Cowen & Co.

Cerus Corp. (Concord, Calif.; CERS) (lead)

3/14/13

$4.20

$6.45

$35.00

54%

Cowen & Co.

Chemocentryx Inc. (Mountain View, Calif.; CCXI)

4/17/13

$12.00

$5.79

$60.00

-52%

Cowen & Co.

Chimerix Inc. (Research Triangle Park, N.C.; CMRX) (co-lead) (IPO)

4/11/13

$14.00

$15.11

$102.50

8%

Cowen & Co.

Epizyme Inc. (Cambridge, Mass.; EPZM) (co-lead) (IPO)

5/31/13

$15.00

$20.80

$88.70

39%

Cowen & Co.

Fate Therapeutics Inc. (San Diego; FATE) (co-lead) (IPO)

10/1/13

$6.00

$6.28

$46.20

5%

Cowen & Co.

GW Pharma plc (Wilshire, UK; GWPH) (co-lead) (IPO)

5/1/13

$8.90

$41.54

$31.15

367%

Cowen & Co.

Hyperion Therapeutics Inc. (South San Francisco; HPTX) (co-lead)

3/8/13

$20.75

$20.22

$67.00

-3%

Cowen & Co.

Immunomedics Inc. (Morris Plains, N.J.; IMMU) (co-lead)

2/22/13

$2.30

$4.60

$14.00

100%

Cowen & Co.

Inovio Pharmaceuticals Inc. (Blue Bell, Pa.; NYSE:INO) (lead)

3/7/13

$0.55

$2.90

$15.06

427%

Cowen & Co.

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD)

5/22/13

$13.00

$11.61

$145.60

-11%

Cowen & Co.

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS)

5/9/13

$19.00

$39.84

$182.70

110%

Cowen & Co.

Mei Pharma Inc. (San Diego; MEIP) (co-lead)

4/5/13

$7.50

$8.01

$15.20

7%

Cowen & Co.

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (IPO)

5/22/13

$14.50

$25.75

$122.10

78%

Cowen & Co.

PTC Therapeutics Inc. (South Plainfield, N.J.; PTCT) (IPO)

6/20/13

$15.00

$16.97

$144.48

13%

Cowen & Co.

Regulus Therapeutics Inc. (La Jolla, Calif.; RGLS) (co-lead)

7/17/13

$9.50

$7.39

$49.20

-22%

Cowen & Co.

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

1/3/13

$47.53

$64.72

$118.83

36%

Cowen & Co.

Xoma Corp. (Berkeley, Calif.; XOMA)

12/13/13

$5.25

$6.73

$57.23

28%

Craig Hallum Capital Group

Mimedx Group Inc. (Marietta, Ga.; MDXG) (co-lead)

12/12/13

$6.80

$8.74

$34.00

29%

Credit Suisse

Bind Therapeutics Inc. (Cambridge, Mass.; BIND) (co-lead) (IPO)

9/20/13

$15.00

$15.09

$70.50

1%

Credit Suisse

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (co-lead)

10/17/13

$23.75

$25.75

$105.90

8%

Credit Suisse

Prothena Corp. plc (Dublin; PRTA) (co-lead)

10/13/13

$22.00

$26.52

$77.00

21%

Credit Suisse

Clovis Oncology Inc. (Boulder, Colo.; CLVS) (co-lead)

6/12/13

$72.00

$60.27

$275.00

-16%

Credit Suisse

Durata Therapeutics Inc. (Chicago; DRTX) (co-lead)

4/12/13

$7.00

$12.79

$50.05

83%

Credit Suisse

Enanta Pharmaceuticals Inc. (Watertown, Mass.; ENTA) (co-lead) (IPO)

3/21/13

$14.00

$27.28

$64.40

95%

Credit Suisse

Esperion Therapeutics Inc. (Plymouth, Mich.; ESPR) (co-lead) (IPO)

6/26/13

$14.00

$13.74

$80.50

-2%

Credit Suisse

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (co-lead) (IPO)

5/22/13

$14.50

$25.75

$122.10

78%

Credit Suisse

PTC Therapeutics Inc. (South Plainfield, N.J.; PTCT) (co-lead) (IPO)

6/20/13

$15.00

$16.97

$144.48

13%

Credit Suisse

Receptos Inc. (San Diego; RCPT) (co-lead) (IPO)

5/9/13

$14.00

$28.99

$72.80

107%

Credit Suisse

Synergy Pharmaceuticals Inc. (New York; SGYP) (lead)

4/9/13

$5.50

$5.63

$90.00

2%

Credit Suisse

Xencor Inc. (Redwood City, Calif.; XNCR) (co-lead) (IPO)

12/3/13

$5.50

$9.14

$80.30

66%

Credit Suisse

Xoma Corp. (Berkeley, Calif.; XOMA) (co-lead)

12/13/13

$5.25

$6.73

$57.23

28%

CRT Capital

Adamis Pharmaceuticals Corp. (San Diego; ADMP) (lead)

12/16/13

$5.95

$6.39

$22.00

7%

CRT Capital

Sorrento Therapeutics Inc. (San Diego; SRNE)

10/28/13

$7.25

$8.10

$34.58

12%

Dawson James

Arca Biopharma Inc. (Broomfield, Colo.; ABIO)12

5/30/13

$1.60

$1.68

$20.00

5%

Dawson James

Arrowhead Research Corp. (Pasadena, Calif.; ARWR) (lead)

1/25/13

$2.12

$10.85

$3.50

412%

Dawson James

Cel-Sci Corp. (Vienna, Va.; NYSE:CVM) (co-lead)

12/20/13

$0.63

$0.59

$3.30

-6%

Dawson James

Novelos Therapeutics Inc. (Madison, Wis.; NVLT) (co-lead)

2/14/13

$0.50

$0.37

$5.50

-26%

Dawson James

Oculus Innovative Sciences Inc.5 (Petaluma, Calif.; OCLS)

3/7/13

$2.80

$3.48

$3.45

24%

 

Dawson James

Tonix Pharmaceuticals Holding Corp. (New York; TNXP)

8/9/13

$4.25

$10.31

$11.39

143%

Deutsche Bank Securities

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY)

1/16/13

$20.13

$64.30

$185.20

219%

Deutsche Bank Securities

Tesaro Inc. (Waltham, Mass.; TSRO)

3/1/13

$18.00

$28.24

$97.20

57%

Feltl & Co.

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (IPO)

5/22/13

$8.00

$18.00

$25.00

125%

Feltl & Co.

Evoke Pharma Inc. (San Diego; EVOK) (IPO)

9/25/13

$12.00

$7.45

$28.98

-38%

Goldman Sachs & Co.

Agios Pharmaceuticals Inc. (Cambridge, Mass.; AGIO) (co-lead) (IPO)

7/24/13

$18.00

$23.95

$120.60

33%

Goldman Sachs & Co.

Chemocentryx Inc. (Mountain View, Calif.; CCXI) (co-lead)

4/17/13

$12.00

$5.79

$60.00

-52%

Goldman Sachs & Co.

Intermune Inc. (Brisbane, Calif.; ITMN) (co-lead)

11/6/13

$13.00

$14.73

$84.50

13%

Goldman Sachs & Co.

Intermune Inc. (Brisbane, Calif.; ITMN) (co-lead)

1/16/13

$9.90

$14.73

$133.65

49%

Goldman Sachs & Co.

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS) (co-lead)

5/9/13

$19.00

$39.84

$182.70

110%

Goldman Sachs & Co.

Synageva Biopharma Corp. (Lexington, Mass.; GEVA) (lead)

9/25/13

$56.63

$64.72

$178.95

14%

Griffin Securities

Fibrocell Science Inc. (Exton, Pa.; FCSC)

9/26/13

$4.10

$4.06

$50.43

-1%

Griffin Securities

Oragenics Inc. (Tampa, Fla.; OGEN) (lead)

11/15/13

$2.50

$2.81

$11.00

12%

Griffin Securities

Ziopharm Oncology Inc. (Boston; ZIOP)

10/24/13

$3.50

$4.34

$50.05

24%

Guggenheim Securities

Acelrx Pharmaceuticals Inc. (Redwood City, Calif.; ACRX)

7/17/13

$11.65

$11.31

$50.90

-3%

Guggenheim Securities

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Guggenheim Securities

Five Prime Therapeutics Inc. (South San Francisco; FPRX) (IPO)

9/18/13

$13.00

$16.79

$71.80

29%

Guggenheim Securities

Tetralogic Pharmaceuticals Inc. (Malvern, Pa.; TLOG) (co-lead) (IPO)

12/12/13

$7.00

$9.52

$50.05

36%

Guggenheim Securities

Tetraphase Pharmaceuticals Inc. (Watertown, Mass; TTPH)

11/4/13

$10.00

$13.52

$49.00

35%

Guggenheim Securities

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

H.C. Wainwright & Co.

Cytrx Corp. (Los Angeles; CYTR)

10/10/13

$2.25

$6.27

$25.90

179%

Janney Montgomery

Cyclacel Pharmaceuticals Inc. (Berkeley Heights, N.J.; CYCC)

5/16/13

$3.00

$4.02

$20.50

34%

Janney Montgomery

Durect Corp. (Cupertino, Calif.; DRRX)

11/8/13

$1.40

$1.73

$11.50

24%

Janney Montgomery

Intercept Pharmaceuticals Inc. (New York; ICPT)

6/19/13

$33.01

$68.28

$65.69

107%

Janney Montgomery

Onconova Therapeutics Inc. (Newtown, Pa.; ONTX) (IPO)

7/25/13

$15.00

$11.48

$88.50

-23%

Jefferies & Co.

A.P. Pharma Inc. (Redwood City, Calif.; OTCBB:APPA) (co-lead)

11/21/13

$0.40

$0.45

$60.00

13%

Jefferies & Co.

Acadia Pharmaceuticals Inc. (San Diego; ACAD) (co-lead)

5/15/13

$12.50

$24.99

$115.00

100%

Jefferies & Co.

Acelrx Pharmaceuticals Inc. (Redwood City, Calif.; ACRX) (co-lead)

7/17/13

$11.65

$11.31

$50.90

-3%

Jefferies & Co.

Aegerion Pharmaceuticals Inc. (Cambridge, Mass.; AEGR) (co-lead)

1/14/13

$26.64

$70.96

$72.05

166%

Jefferies & Co.

Amarin Corp. plc (Dublin; AMRN) (co-lead)

7/10/13

$5.60

$1.97

$121.52

-65%

Jefferies & Co.

Anthera Pharmaceuticals Inc.6 (Hayward, Calif.; ANTH) (lead)

1/24/13

$5.28

$3.07

$40.00

-42%

Jefferies & Co.

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA) (co-lead)

1/24/13

$19.60

$6.82

$323.40

-65%

Jefferies & Co.

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX) (co-lead)

12/5/13

$24.50

$24.21

$191.40

-1%

Jefferies & Co.

Celldex Therapeutics Inc. (Needham, Mass.; CLDX) (co-lead)

2/6/13

$7.50

$24.21

$103.50

223%

Jefferies & Co.

Durata Therapeutics Inc. (Chicago; DRTX) (co-lead)

4/12/13

$7.00

$12.79

$50.05

83%

Jefferies & Co.

Dyax Corp. (Burlington, Mass.; DYAX) (lead)

10/10/13

$6.50

$7.54

$60.00

16%

Jefferies & Co.

Five Prime Therapeutics Inc. (South San Francisco; FPRX) (co-lead) (IPO)

9/18/13

$13.00

$16.79

$71.80

29%

Jefferies & Co.

Kamada Ltd. (Ness Ziona, Israel; KMDA) (co-lead) (IPO)

5/31/13

$9.25

$14.87

$51.64

61%

Jefferies & Co.

Mirati Therapeutics Inc. (San Diego; MRTX) (co-lead)

10/24/13

$17.50

$16.63

$56.90

-5%

Jefferies & Co.

Newlink Genetics Corp. (Ames, Iowa; NLNK) (lead)

1/31/13

$11.40

$22.01

$52.44

93%

Jefferies & Co.

Oncomed Pharmaceuticals Inc. (Redwood City, Calif.; OMED) (co-lead) (IPO)

7/18/13

$17.00

$29.52

$93.50

74%

Jefferies & Co.

Progenics Pharmaceuticals Inc. (Tarrytown, N.Y.; PGNX) (lead)

6/21/13

$4.40

$5.33

$37.40

21%

Jefferies & Co.

Sagent Pharmaceuticals Inc. (Schaumburg, Ill.; SGNT) (co-lead)

9/11/13

$21.25

$25.38

$75.28

19%

Jefferies & Co.

Synta Pharmaceuticals Corp. (Lexington, Mass.; SNTA) (lead)

11/14/13

$3.75

$5.24

$60.38

40%

Jefferies & Co.

Verastem Inc. (Cambridge, Mass.; VSTM) (co-lead)

7/18/13

$15.00

$11.40

$64.50

-24%

Jefferies & Co.

Xoma Corp. (Berkeley, Calif.; XOMA) (co-lead)

12/13/13

$5.25

$6.73

$57.23

28%

JMP Securities

A.P. Pharma Inc. (Redwood City, Calif.; OTCBB:APPA)

11/21/13

$0.40

$0.45

$60.00

13%

JMP Securities

Acadia Pharmaceuticals Inc. (San Diego; ACAD)

5/15/13

$12.50

$24.99

$115.00

100%

JMP Securities

Acceleron Pharma Inc. (Cambridge, Mass.; XLRN) (IPO)

9/19/13

$15.00

$39.60

$96.26

164%

JMP Securities

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN)

3/1/13

$8.40

$3.32

$141.96

-60%

JMP Securities

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (co-lead)

10/25/13

$16.50

$18.00

$37.95

9%

JMP Securities

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY)

1/16/13

$20.13

$64.30

$185.20

219%

JMP Securities

Axogen Inc. (Alachua, Fla.; AXGN) (lead)

8/9/13

$3.00

$4.49

$18.60

50%

JMP Securities

Bind Therapeutics Inc. (Cambridge, Mass.; BIND) (IPO)

9/20/13

$15.00

$15.09

$70.50

1%

JMP Securities

Biocryst Pharmaceuticals Inc. (Research Triangle Park, N.C.; BCRX) (co-lead)

8/2/13

$4.40

$7.60

$20.20

73%

JMP Securities

Chelsea Therapeutics International Ltd. (Charlotte, N.C.; CHTP) (lead)

11/14/13

$3.00

$4.43

$23.10

48%

JMP Securities

Conatus Pharmaceuticals Inc. (San Diego; CNAT) (IPO)

7/25/13

$11.00

$6.45

$66.00

-41%

JMP Securities

Cyclacel Pharmaceuticals Inc. (Berkeley Heights, N.J.; CYCC) (lead)

5/16/13

$3.00

$4.02

$20.50

34%

JMP Securities

Durata Therapeutics Inc. (Chicago; DRTX)

4/12/13

$7.00

$12.79

$50.05

83%

JMP Securities

Enanta Pharmaceuticals Inc. (Watertown, Mass.; ENTA) (IPO)

3/21/13

$14.00

$27.28

$64.40

95%

JMP Securities

Epizyme Inc. (Cambridge, Mass.; EPZM) (IPO)

5/31/13

$15.00

$20.80

$88.70

39%

JMP Securities

Esperion Therapeutics Inc. (Plymouth, Mich.; ESPR) (IPO)

6/26/13

$14.00

$13.74

$80.50

-2%

JMP Securities

Galena Biopharma Inc. (Portland, Ore.; GALE)

9/13/13

$2.00

$4.96

$40.25

148%

JMP Securities

Hyperion Therapeutics Inc. (South San Francisco; HPTX)

3/8/13

$20.75

$20.22

$67.00

-3%

JMP Securities

Insys Therapeutics Inc. (Phoenix; INSY) (co-lead) (IPO)

5/2/13

$8.00

$38.71

$32.00

384%

JMP Securities

Intermune Inc. (Brisbane, Calif.; ITMN)

11/6/13

$13.00

$14.73

$84.50

13%

JMP Securities

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO)

9/26/13

$4.00

$4.42

$30.00

11%

JMP Securities

Karyopharm Therapeutics Inc. (Natick, Mass.; KPTI) (IPO)

11/7/13

$16.00

$22.92

$125.12

43%

JMP Securities

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

JMP Securities

Organovo Holdings Inc. (San Diego; NYSE:ONVO)

8/2/13

$4.50

$11.07

$46.58

146%

JMP Securities

Sangamo Biosciences Inc. (Richmond, Calif.; SGMO) (co-lead)

9/19/13

$10.58

$13.89

$74.22

31%

JMP Securities

Synta Pharmaceuticals Corp. (Lexington, Mass.; SNTA)

11/14/13

$3.75

$5.24

$60.38

40%

JMP Securities

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH) (IPO)

3/20/13

$7.00

$13.52

$80.58

93%

JMP Securities

Tetraphase Pharmaceuticals Inc. (Watertown, Mass; TTPH)

11/4/13

$10.00

$13.52

$49.00

35%

JMP Securities

Vanda Pharmaceuticals Inc. (Washington; VNDA)

8/7/13

$11.14

$12.41

$52.14

11%

JMP Securities

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

JMP Securities

Ziopharm Oncology Inc. (Boston; ZIOP)

10/24/13

$3.50

$4.34

$50.05

24%

JP Morgan

Aegerion Pharmaceuticals Inc. (Cambridge, Mass.; AEGR) (co-lead)

1/14/13

$26.64

$70.96

$72.05

166%

JP Morgan

Agios Pharmaceuticals Inc. (Cambridge, Mass.; AGIO) (co-lead) (IPO)

7/24/13

$18.00

$23.95

$120.60

33%

JP Morgan

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY) (co-lead)

1/16/13

$20.13

$64.30

$185.20

219%

JP Morgan

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA) (co-lead)

1/24/13

$19.60

$6.82

$323.40

-65%

JP Morgan

Aveo Oncology Inc. (Cambridge, Mass.; AVEO) (lead)

1/17/13

$7.50

$1.83

$57.75

-76%

JP Morgan

Bluebird Bio Inc. (Cambridge, Mass.; BLUE) (co-lead) (IPO)

6/19/13

$17.00

$20.98

$116.11

23%

JP Morgan

Chemocentryx Inc. (Mountain View, Calif.; CCXI) (co-lead)

4/17/13

$12.00

$5.79

$60.00

-52%

JP Morgan

Clovis Oncology Inc. (Boulder, Colo.; CLVS) (co-lead)

6/12/13

$72.00

$60.27

$275.00

-16%

JP Morgan

Enanta Pharmaceuticals Inc. (Watertown, Mass.; ENTA) (co-lead) (IPO)

3/21/13

$14.00

$27.28

$64.40

95%

JP Morgan

Intermune Inc. (Brisbane, Calif.; ITMN) (co-lead)

1/16/13

$9.90

$14.73

$133.65

49%

JP Morgan

Intermune Inc. (Brisbane, Calif.; ITMN) (co-lead)

11/6/13

$13.00

$14.73

$84.50

13%

JP Morgan

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD) (co-lead)

5/22/13

$13.00

$11.61

$145.60

-11%

JP Morgan

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS) (co-lead)

5/9/13

$19.00

$39.84

$182.70

110%

JP Morgan

Keryx Biopharmaceuticals Inc. (New York; KERX) (lead)

1/31/13

$8.49

$12.95

$69.90

53%

JP Morgan

Kythera Biopharmaceuticals Inc. (Calabasas, Calif.; KYTH) (co-lead)

10/9/13

$45.75

$37.35

$120.00

-18%

JP Morgan

NPS Pharmaceuticals Inc. (Bedminster, N.J.; NPSP) (co-lead)

5/20/13

$14.53

$30.36

$100.26

109%

JP Morgan

 

Ophthotech Corp. (New York; OPHT) (co-lead) (IPO)

9/25/13

$22.00

$32.35

$192.28

47%

JP Morgan

Pharmacyclics Inc. (Sunnyvale, Calif.; PCYC) (lead)

3/8/13

$94.20

$105.78

$207.24

12%

JP Morgan

Prosensa Holding BV (Leiden, the Netherlands; RNA) (co-lead) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

JP Morgan

PTC Therapeutics Inc. (South Plainfield, N.J.; PTCT) (co-lead) (IPO)

6/20/13

$15.00

$16.97

$144.48

13%

JP Morgan

Synageva Biopharma Corp. (Lexington, Mass.; GEVA) (co-lead)

1/3/13

$47.53

$64.72

$118.83

36%

JP Morgan

Ziopharm Oncology Inc. (Boston; ZIOP) (lead)

10/24/13

$3.50

$4.34

$50.05

24%

KBC Securities

Prosensa Holding BV (Leiden, the Netherlands; RNA) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

Ladenburg Thalmann

Acadia Pharmaceuticals Inc. (San Diego; ACAD)

5/15/13

$12.50

$24.99

$115.00

100%

Ladenburg Thalmann

Adma Biologics Inc. (Hackensack, N.J.; OTCBB:ADMA) (IPO)

10/17/13

$8.50

$7.80

$28.50

-8%

Ladenburg Thalmann

Axogen Inc. (Alachua, Fla.; AXGN)

8/9/13

$3.00

$4.49

$18.60

50%

Ladenburg Thalmann

Biodel Inc. (Danbury, Conn.; BIOD)

6/20/13

$4.35

$2.28

$19.49

-48%

Ladenburg Thalmann

Chelsea Therapeutics International Ltd. (Charlotte, N.C.; CHTP)

11/14/13

$3.00

$4.43

$23.10

48%

Ladenburg Thalmann

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD)

5/22/13

$13.00

$11.61

$145.60

-11%

Ladenburg Thalmann

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Ladenburg Thalmann

Lipocine Inc. (Salt Lake City; OCTQB:LPCN) (lead)

11/27/13

$8.25

$8.25

$12.30

0%

Ladenburg Thalmann

Navidea Biopharmaceuticals Inc. (Dublin, Ohio; NAVB) (lead)

1/31/13

$3.10

$2.07

$4.78

-33%

Ladenburg Thalmann

Oxygen Biotherapeutics Inc.1 (Morrisville, N.C.; OXBT) (lead)

7/22/13

$1.95

$4.50

$5.40

131%

Ladenburg Thalmann

Psivida Corp. (Watertown, Mass.; PSDV) (lead)

7/18/13

$3.10

$3.97

$10.80

28%

Ladenburg Thalmann

Repros Therapeutics Inc. (The Woodlands, Texas; RPRX)

6/20/13

$19.00

$18.30

$81.94

-4%

Ladenburg Thalmann

TG Therapeutics Inc. (New York; TGTX) (co-lead)

7/18/13

$6.15

$3.90

$35.10

-37%

Laidlaw & Co.

Adma Biologics Inc. (Hackensack, N.J.; OTCBB:ADMA) (IPO)

10/17/13

$8.50

$7.80

$28.50

-8%

Laidlaw & Co.

Cel-Sci Corp. (Vienna, Va.; NYSE Amex:CVM) (co-lead)

10/9/13

$1.00

$0.59

$17.80

-41%

Laidlaw & Co.

Cel-Sci Corp. (Vienna, Va.; NYSE:CVM) (co-lead)

12/20/13

$0.63

$0.59

$3.30

-6%

Lake Street Capital Markets

Mimedx Group Inc. (Marietta, Ga.; MDXG)

12/12/13

$6.80

$8.74

$34.00

29%

Lazard Capital

Apricus Biosciences Inc. (San Diego; APRI) (lead)

5/24/13

$2.85

$2.65

$17.10

-7%

Lazard Capital

Chimerix Inc. (Research Triangle Park, N.C.; CMRX) (IPO)

4/11/13

$14.00

$15.11

$102.50

8%

Lazard Capital

Discovery Laboratories Inc. (Warrington, Pa.; DSCO)

11/1/13

$2.00

$2.25

$50.00

13%

Lazard Capital

GW Pharma plc (Wilshire, UK; GWPH) (co-lead) (IPO)

5/1/13

$8.90

$41.54

$31.15

367%

Lazard Capital

Insmed Inc. (Monmouth Junction, N.J.; INSM)

7/17/13

$10.40

$17.00

$62.40

63%

Lazard Capital

Macrogenics Inc. (Rockville, Md.; MGNX) (IPO)

10/11/13

$16.00

$27.43

$92.00

71%

Lazard Capital

Novavax Inc. (Rockville, Md.; NVAX) (lead)

9/24/13

$3.14

$5.12

$99.85

63%

Lazard Capital

Organovo Holdings Inc. (San Diego; NYSE:ONVO) (co-lead)

8/2/13

$4.50

$11.07

$46.58

146%

Lazard Capital

Regulus Therapeutics Inc. (La Jolla, Calif.; RGLS) (co-lead)

7/17/13

$9.50

$7.39

$49.20

-22%

Lazard Capital

Repros Therapeutics Inc. (The Woodlands, Texas; RPRX)

6/20/13

$19.00

$18.30

$81.94

-4%

Lazard Capital

Sangamo Biosciences Inc. (Richmond, Calif.; SGMO) (co-lead)

9/19/13

$10.58

$13.89

$74.22

31%

Lazard Capital

Sophiris Bio Inc. (San Diego; SPHS) (IPO)

8/16/13

$5.00

$3.70

$65.00

-26%

Lazard Capital

Vanda Pharmaceuticals Inc. (Washington; VNDA) (co-lead)

8/7/13

$11.14

$12.41

$52.14

11%

Lazard Capital

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

Lazard Capital

Cerus Corp. (Concord, Calif.; CERS)

3/14/13

$4.20

$6.45

$35.00

54%

Leerink Swann

A.P. Pharma Inc. (Redwood City, Calif.; OTCBB:APPA) (co-lead)

11/21/13

$0.40

$0.45

$60.00

13%

Leerink Swann

Acceleron Pharma Inc. (Cambridge, Mass.; XLRN) (co-lead) (IPO)

9/19/13

$15.00

$39.60

$96.26

164%

Leerink Swann

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN) (co-lead)

3/1/13

$8.40

$3.32

$141.96

-60%

Leerink Swann

Aegerion Pharmaceuticals Inc. (Cambridge, Mass.; AEGR)

1/14/13

$26.64

$70.96

$72.05

166%

Leerink Swann

Agios Pharmaceuticals Inc. (Cambridge, Mass.; AGIO) (IPO)

7/24/13

$18.00

$23.95

$120.60

33%

Leerink Swann

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY)

1/16/13

$20.13

$64.30

$185.20

219%

Leerink Swann

Ambit Biosciences Inc. (San Diego; AMBI) (co-lead) (IPO)

5/16/13

$8.00

$9.64

$65.00

21%

Leerink Swann

Anthera Pharmaceuticals Inc.6 (Hayward, Calif.; ANTH)

1/24/13

$5.28

$3.07

$40.00

-42%

Leerink Swann

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA)

1/24/13

$19.60

$6.82

$323.40

-65%

Leerink Swann

Celldex Therapeutics Inc. (Needham, Mass.; CLDX) (co-lead)

2/6/13

$7.50

$24.21

$103.50

223%

Leerink Swann

Clovis Oncology Inc. (Boulder, Colo.; CLVS)

6/12/13

$72.00

$60.27

$275.00

-16%

Leerink Swann

Dyax Corp. (Burlington, Mass.; DYAX)

10/10/13

$6.50

$7.54

$60.00

16%

Leerink Swann

Intermune Inc. (Brisbane, Calif.; ITMN)

11/6/13

$13.00

$14.73

$84.50

13%

Leerink Swann

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO) (lead)

9/26/13

$4.00

$4.42

$30.00

11%

Leerink Swann

Karyopharm Therapeutics Inc. (Natick, Mass.; KPTI) (co-lead) (IPO)

11/7/13

$16.00

$22.92

$125.12

43%

Leerink Swann

Kythera Biopharmaceuticals Inc. (Calabasas, Calif.; KYTH) (co-lead)

10/9/13

$45.75

$37.35

$120.00

-18%

Leerink Swann

Macrogenics Inc. (Rockville, Md.; MGNX) (co-lead) (IPO)

10/11/13

$16.00

$27.43

$92.00

71%

Leerink Swann

Mirati Therapeutics Inc. (San Diego; MRTX) (co-lead)

10/24/13

$17.50

$16.63

$56.90

-5%

Leerink Swann

Ophthotech Corp. (New York; OPHT) (IPO)

9/25/13

$22.00

$32.35

$192.28

47%

Leerink Swann

Sophiris Bio Inc. (San Diego; SPHS) (co-lead) (IPO)

8/16/13

$5.00

$3.70

$65.00

-26%

Leerink Swann

Zogenix Inc. (San Diego; ZGNX) (co-lead)

11/4/13

$2.25

$3.44

$68.85

53%

Leerink Swann

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX) (co-lead)

12/5/13

$24.50

$24.21

$191.40

-1%

Leerink Swann

Enanta Pharmaceuticals Inc. (Watertown, Mass.; ENTA) (IPO)

3/21/13

$14.00

$27.28

$64.40

95%

Leerink Swann

Epizyme Inc. (Cambridge, Mass.; EPZM) (co-lead) (IPO)

5/31/13

$15.00

$20.80

$88.70

39%

Leerink Swann

Hyperion Therapeutics Inc. (South San Francisco; HPTX) (co-lead)

3/8/13

$20.75

$20.22

$67.00

-3%

Leerink Swann

Insmed Inc. (Monmouth Junction, N.J.; INSM) (lead)

7/17/13

$10.40

$17.00

$62.40

63%

Leerink Swann

Intermune Inc. (Brisbane, Calif.; ITMN)

1/16/13

$9.90

$14.73

$133.65

49%

Leerink Swann

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO) (lead) (IPO)

1/31/13

$8.00

$4.42

$70.00

-45%

Leerink Swann

NPS Pharmaceuticals Inc. (Bedminster, N.J.; NPSP)

5/20/13

$14.53

$30.36

$100.26

109%

Leerink Swann

Omthera Pharmaceuticals Inc.2 (Princeton, N.J.; OMTH) (co-lead) (IPO)

4/12/13

$8.00

$12.70

$64.00

59%

Leerink Swann

Oncomed Pharmaceuticals Inc. (Redwood City, Calif.; OMED) (co-lead) (IPO)

7/18/13

$17.00

$29.52

$93.50

74%

Leerink Swann

Onconova Therapeutics Inc. (Newtown, Pa.; ONTX) (co-lead) (IPO)

7/25/13

$15.00

$11.48

$88.50

-23%

Leerink Swann

Prosensa Holding BV (Leiden, the Netherlands; RNA) (co-lead) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

Leerink Swann

Receptos Inc. (San Diego; RCPT) (co-lead) (IPO)

5/9/13

$14.00

$28.99

$72.80

107%

Leerink Swann

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

1/3/13

$47.53

$64.72

$118.83

36%

Leerink Swann

Tesaro Inc. (Waltham, Mass.; TSRO)

3/1/13

$18.00

$28.24

$97.20

57%

Leerink Swann

Trius Therapeutics Inc.7 (San Diego; TSRX) (co-lead)

1/18/13

$4.75

$13.63

$34.20

187%

Leerink Swann

Verastem Inc. (Cambridge, Mass.; VSTM) (co-lead)

7/18/13

$15.00

$11.40

$64.50

-24%

Leerink Swann

Xencor Inc. (Redwood City, Calif.; XNCR) (co-lead) (IPO)

12/3/13

$5.50

$9.14

$80.30

66%

Maxim Group LLC

Aastrom Biosciences Inc.3 (Ann Arbor, Mich.; ASTM) (co-lead)

8/14/13

$6.00

$3.23

$8.70

-46%

Maxim Group LLC

Adma Biologics Inc. (Hackensack, N.J.; OTCBB:ADMA) (IPO)

10/17/13

$8.50

$7.80

$28.50

-8%

Maxim Group LLC

Aeterna Zentaris Inc. (Quebec City; AEZS)

11/20/13

$1.15

$1.38

$15.00

20%

Maxim Group LLC

Brainstorm Cell Therapeutics Inc. (New York; OTCQB:BCLI) (co-lead)

8/13/13

$0.17

$0.18

$4.00

6%

Maxim Group LLC

Galena Biopharma Inc. (Portland, Ore.; GALE)

9/13/13

$2.00

$4.96

$40.25

148%

Maxim Group LLC

Inovio Pharmaceuticals Inc. (Blue Bell, Pa.; NYSE:INO)

3/7/13

$0.55

$2.90

$15.06

427%

Maxim Group LLC

Intellipharmaceutics International Inc. (Toronto; IPCI) (lead)

8/1/13

$2.05

$3.71

$3.10

81%

Maxim Group LLC

Medgenics Inc. (San Francisco; MDGN) (lead)

3/26/13

$5.25

$5.99

$31.87

14%

Maxim Group LLC

Organovo Holdings Inc. (San Diego; NYSE:ONVO)

8/2/13

$4.50

$11.07

$46.58

146%

Maxim Group LLC

Stemcells Inc. (Newark, Calif.; STEM) (co-lead)

10/2/13

$1.45

$1.23

$18.63

-15%

Maxim Group LLC

Tekmira Pharmaceuticals Corp. (Vancouver, British Columbia; TKMR)

10/18/13

$8.00

$7.97

$35.00

0%

MDB Capital Group

Imprimis Pharmaceuticals Inc. (Solana Beach, Calif.; IMMY) (co-lead)

2/11/13

$5.25

$3.36

$9.66

-36%

Mizuho Securities

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD)

5/22/13

$13.00

$11.61

$145.60

-11%

MLV & Co.

Galena Biopharma Inc. (Portland, Ore.; GALE)

9/13/13

$2.00

$4.96

$40.25

148%

MLV & Co.

Medgenics Inc. (San Francisco; MDGN)

3/26/13

$5.25

$5.99

$31.87

14%

MLV & Co.

Psivida Corp. (Watertown, Mass.; PSDV)

7/18/13

$3.10

$3.97

$10.80

28%

Morgan Stanley

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY) (co-lead)

1/16/13

$20.13

$64.30

$185.20

219%

Morgan Stanley

Chimerix Inc. (Research Triangle Park, N.C.; CMRX) (co-lead) (IPO)

4/11/13

$14.00

$15.11

$102.50

8%

Morgan Stanley

Ironwood Pharmaceuticals Inc. (Cambridge, Mass.; IRWD) (co-lead)

5/22/13

$13.00

$11.61

$145.60

-11%

Morgan Stanley

Kamada Ltd. (Ness Ziona, Israel; KMDA) (co-lead) (IPO)

5/31/13

$9.25

$14.87

$51.64

61%

Morgan Stanley

NPS Pharmaceuticals Inc. (Bedminster, N.J.; NPSP) (co-lead)

5/20/13

$14.53

$30.36

$100.26

109%

Morgan Stanley

Ophthotech Corp. (New York; OPHT) (co-lead) (IPO)

9/25/13

$22.00

$32.35

$192.28

47%

Morgan Stanley

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (co-lead)

10/17/13

$23.75

$25.75

$105.90

8%

Morgan Stanley

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (co-lead) (IPO)

5/22/13

$14.50

$25.75

$122.10

78%

Morgan Stanley

Relypsa Inc. (Redwood City, Calif.; RLYP) (co-lead) (IPO)

11/15/13

$11.00

$25.00

$85.80

127%

Morgan Stanley

Sagent Pharmaceuticals Inc. (Schaumburg, Ill.; SGNT) (co-lead)

9/11/13

$21.25

$25.38

$75.28

19%

Morgan Stanley

Synageva Biopharma Corp. (Lexington, Mass.; GEVA)

9/25/13

$56.63

$64.72

$178.95

14%

Morgan Stanley

Synageva Biopharma Corp. (Lexington, Mass.; GEVA) (co-lead)

1/3/13

$47.53

$64.72

$118.83

36%

Morgan Stanley

Tesaro Inc. (Waltham, Mass.; TSRO) (co-lead)

3/1/13

$18.00

$28.24

$97.20

57%

National Securities Corp.

Lipocine Inc. (Salt Lake City; OCTQB:LPCN)

11/27/13

$8.25

$8.25

$12.30

0%

National Securities Corp.

Medgenics Inc. (San Francisco; MDGN)

3/26/13

$5.25

$5.99

$31.87

14%

National Securities Corp.

TG Therapeutics Inc. (New York; TGTX)

7/18/13

$6.15

$3.90

$35.10

-37%

National Securities Corp.

Tonix Pharmaceuticals Holding Corp. (New York; TNXP)

8/9/13

$4.25

$10.31

$11.39

143%

Needham & Co.

Acadia Pharmaceuticals Inc. (San Diego; ACAD)

5/15/13

$12.50

$24.99

$115.00

100%

Needham & Co.

Aerie Pharmaceuticals Inc. (Bedminster, N.J.; AERI) (IPO)

10/28/13

$10.00

$17.96

$77.20

80%

Needham & Co.

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY)

1/16/13

$20.13

$64.30

$185.20

219%

Needham & Co.

Cempra Inc. (Chapel Hill, N.C.; CEMP)

6/14/13

$7.00

$12.39

$57.75

77%

Needham & Co.

Chelsea Therapeutics International Ltd. (Charlotte, N.C.; CHTP)

11/14/13

$3.00

$4.43

$23.10

48%

Needham & Co.

Dyax Corp. (Burlington, Mass.; DYAX)

10/10/13

$6.50

$7.54

$60.00

16%

Needham & Co.

Hyperion Therapeutics Inc. (South San Francisco; HPTX)

3/8/13

$20.75

$20.22

$67.00

-3%

Needham & Co.

Intercept Pharmaceuticals Inc. (New York; ICPT)

6/19/13

$33.01

$68.28

$65.69

107%

Needham & Co.

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS)

5/9/13

$19.00

$39.84

$182.70

110%

Needham & Co.

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO)

9/26/13

$4.00

$4.42

$30.00

11%

Needham & Co.

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO) (IPO)

1/31/13

$8.00

$4.42

$70.00

-45%

Needham & Co.

Progenics Pharmaceuticals Inc. (Tarrytown, N.Y.; PGNX)

6/21/13

$4.40

$5.33

$37.40

21%

Needham & Co.

Regado Biosciences Inc. (Basking Ridge, N.J.; RGDO) (IPO)

8/22/13

$4.00

$4.77

$46.68

19%

Needham & Co.

Sagent Pharmaceuticals Inc. (Schaumburg, Ill.; SGNT)

9/11/13

$21.25

$25.38

$75.28

19%

Needham & Co.

Tetraphase Pharmaceuticals Inc. (Watertown, Mass; TTPH)

11/4/13

$10.00

$13.52

$49.00

35%

Needham & Co.

Regulus Therapeutics Inc. (La Jolla, Calif.; RGLS)

7/17/13

$9.50

$7.39

$49.20

-22%

Needham & Co.

Tetralogic Pharmaceuticals Inc. (Malvern, Pa.; TLOG) (co-lead) (IPO)

12/12/13

$7.00

$9.52

$50.05

36%

Needham & Co.

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH) (IPO)

3/20/13

$7.00

$13.52

$80.58

93%

Newport Coast Securities

Adamis Pharmaceuticals Corp. (San Diego; ADMP)

12/16/13

$5.95

$6.39

$22.00

7%

Noble Financial Capital

Biocryst Pharmaceuticals Inc. (Research Triangle Park, N.C.; BCRX)

8/2/13

$4.40

$7.60

$20.20

73%

Noble Financial Capital

Galena Biopharma Inc. (Portland, Ore.; GALE)

9/13/13

$2.00

$4.96

$40.25

148%

Northland Capital

Mimedx Group Inc. (Marietta, Ga.; MDXG)

12/12/13

$6.80

$8.74

$34.00

29%

Oppenheimer & Co.

A.P. Pharma Inc. (Redwood City, Calif.; OTCBB:APPA)

11/21/13

$0.40

$0.45

$60.00

13%

Oppenheimer & Co.

Adma Biologics Inc. (Hackensack, N.J.; OTCBB:ADMA) (lead) (IPO)

10/17/13

$8.50

$7.80

$28.50

-8%

Oppenheimer & Co.

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Oppenheimer & Co.

Celldex Therapeutics Inc. (Needham, Mass.; CLDX)

2/6/13

$7.50

$24.21

$103.50

223%

Oppenheimer & Co.

Galena Biopharma Inc. (Portland, Ore.; GALE) (lead)

9/13/13

$2.00

$4.96

$40.25

148%

Oppenheimer & Co.

Immunomedics Inc. (Morris Plains, N.J.; IMMU) (co-lead)

2/22/13

$2.30

$4.60

$14.00

100%

Oppenheimer & Co.

Insys Therapeutics Inc. (Phoenix; INSY) (IPO)

5/2/13

$8.00

$38.71

$32.00

384%

Oppenheimer & Co.

Kamada Ltd. (Ness Ziona, Israel; KMDA) (IPO)

5/31/13

$9.25

$14.87

$51.64

61%

Oppenheimer & Co.

Karyopharm Therapeutics Inc. (Natick, Mass.; KPTI) (IPO)

11/7/13

$16.00

$22.92

$125.12

43%

Oppenheimer & Co.

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Oppenheimer & Co.

Northwest Biotherapeutics Inc. (Bethesda, Md.; NWBO) (lead)

11/21/13

$4.80

$3.77

$23.50

-21%

Oppenheimer & Co.

Organovo Holdings Inc. (San Diego; NYSE:ONVO) (co-lead)

8/2/13

$4.50

$11.07

$46.58

146%

Oppenheimer & Co.

Tetralogic Pharmaceuticals Inc. (Malvern, Pa.; TLOG) (co-lead) (IPO)

12/12/13

$7.00

$9.52

$50.05

36%

Oppenheimer & Co.

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

Oppenheimer & Co.

Zogenix Inc. (San Diego; ZGNX)

11/4/13

$2.25

$3.44

$68.85

53%

Paradigm Capital

Oncolytics Biotech Inc. (Calgary, Alberta; ONCY)

2/21/13

$4.00

$1.55

$32.00

-61%

Piper Jaffray & Co.

Acceleron Pharma Inc. (Cambridge, Mass.; XLRN) (IPO)

9/19/13

$15.00

$39.60

$96.26

164%

Piper Jaffray & Co.

Acelrx Pharmaceuticals Inc. (Redwood City, Calif.; ACRX) (co-lead)

7/17/13

$11.65

$11.31

$50.90

-3%

Piper Jaffray & Co.

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN)

3/1/13

$8.40

$3.32

$141.96

-60%

Piper Jaffray & Co.

Alnylam Pharmaceuticals Inc. (Cambridge, Mass.; ALNY)

1/16/13

$20.13

$64.30

$185.20

219%

Piper Jaffray & Co.

Conatus Pharmaceuticals Inc. (San Diego; CNAT) (co-lead) (IPO)

7/25/13

$11.00

$6.45

$66.00

-41%

Piper Jaffray & Co.

Discovery Laboratories Inc. (Warrington, Pa.; DSCO) (co-lead)

11/1/13

$2.00

$2.25

$50.00

13%

Piper Jaffray & Co.

Idera Pharmaceuticals Inc. (Cambridge, Mass.; IDRA) (lead)

9/26/13

$1.55

$4.63

$27.70

199%

Piper Jaffray & Co.

Idera Pharmaceuticals Inc. (Cambridge, Mass.; IDRA) (lead)

5/2/13

$0.50

$4.63

$16.50

826%

Piper Jaffray & Co.

Mast Therapeutics Inc. (San Diego; MSTX) (co-lead)

6/14/13

$0.50

$0.46

$25.00

-8%

Piper Jaffray & Co.

Mirati Therapeutics Inc. (San Diego; MRTX)

10/24/13

$17.50

$16.63

$56.90

-5%

Piper Jaffray & Co.

Novavax Inc. (Rockville, Md.; NVAX)

9/24/13

$3.14

$5.12

$99.85

63%

Piper Jaffray & Co.

Omthera Pharmaceuticals Inc.2 (Princeton, N.J.; OMTH) (IPO)

4/12/13

$8.00

$12.70

$64.00

59%

Piper Jaffray & Co.

Oncolytics Biotech Inc. (Calgary, Alberta; ONCY) (co-lead)

2/21/13

$4.00

$1.55

$32.00

-61%

Piper Jaffray & Co.

Oncomed Pharmaceuticals Inc. (Redwood City, Calif.; OMED) (IPO)

7/18/13

$17.00

$29.52

$93.50

74%

Piper Jaffray & Co.

Onconova Therapeutics Inc. (Newtown, Pa.; ONTX) (IPO)

7/25/13

$15.00

$11.48

$88.50

-23%

Piper Jaffray & Co.

Sagent Pharmaceuticals Inc. (Schaumburg, Ill.; SGNT)

9/11/13

$21.25

$25.38

$75.28

19%

Piper Jaffray & Co.

Sangamo Biosciences Inc. (Richmond, Calif.; SGMO) (co-lead)

9/19/13

$10.58

$13.89

$74.22

31%

Piper Jaffray & Co.

Vanda Pharmaceuticals Inc. (Washington; VNDA) (co-lead)

8/7/13

$11.14

$12.41

$52.14

11%

Piper Jaffray & Co.

Xoma Corp. (Berkeley, Calif.; XOMA)

12/13/13

$5.25

$6.73

$57.23

28%

RBC Capital Markets

Aerie Pharmaceuticals Inc. (Bedminster, N.J.; AERI) (IPO) (co-lead)

10/28/13

$10.00

$17.96

$77.20

80%

RBC Capital Markets

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA)

1/24/13

$19.60

$6.82

$323.40

-65%

RBC Capital Markets

Aveo Oncology Inc. (Cambridge, Mass.; AVEO)

1/17/13

$7.50

$1.83

$57.75

-76%

RBC Capital Markets

Durata Therapeutics Inc. (Chicago; DRTX)

4/12/13

$7.00

$12.79

$50.05

83%

RBC Capital Markets

Kamada Ltd. (Ness Ziona, Israel; KMDA) (IPO)

5/31/13

$9.25

$14.87

$51.64

61%

RBC Capital Markets

Prothena Corp. plc (Dublin; PRTA) (co-lead)

10/13/13

$22.00

$26.52

$77.00

21%

RBC Capital Markets

Xoma Corp. (Berkeley, Calif.; XOMA)

12/13/13

$5.25

$6.73

$57.23

28%

Roth Capital Partners

Acadia Pharmaceuticals Inc. (San Diego; ACAD)

5/15/13

$12.50

$24.99

$115.00

100%

Roth Capital Partners

Apricus Biosciences Inc. (San Diego; APRI)

5/24/13

$2.85

$2.65

$17.10

-7%

Roth Capital Partners

Brainstorm Cell Therapeutics Inc. (New York; OTCQB:BCLI) (co-lead)

8/13/13

$0.17

$0.18

$4.00

6%

Roth Capital Partners

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Roth Capital Partners

Celldex Therapeutics Inc. (Needham, Mass.; CLDX)

2/6/13

$7.50

$24.21

$103.50

223%

Roth Capital Partners

Delcath Systems Inc. (New York; DCTH) (lead)

10/23/13

$0.36

$0.26

$7.55

-28%

Roth Capital Partners

Discovery Laboratories Inc. (Warrington, Pa.; DSCO)

11/1/13

$2.00

$2.25

$50.00

13%

Roth Capital Partners

Galena Biopharma Inc. (Portland, Ore.; GALE)

9/13/13

$2.00

$4.96

$40.25

148%

Roth Capital Partners

GW Pharma plc (Wilshire, UK; GWPH) (IPO)

5/1/13

$8.90

$41.54

$31.15

367%

Roth Capital Partners

iBio Inc. (Newark, Del.; IBIO) (lead)

4/23/13

$0.48

$0.34

$4.28

-29%

Roth Capital Partners

International Stem Cell Corp. (Carlsbad, Calif.; ISCO) (lead)

7/19/13

$0.15

$0.21

$3.00

40%

Roth Capital Partners

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Roth Capital Partners

Mei Pharma Inc. (San Diego; MEIP)

10/28/13

$8.00

$8.01

$35.00

0%

Roth Capital Partners

Mei Pharma Inc. (San Diego; MEIP)

4/5/13

$7.50

$8.01

$15.20

7%

Roth Capital Partners

Prothena Corp. plc (Dublin; PRTA)

10/13/13

$22.00

$26.52

$77.00

21%

Roth Capital Partners

Stemline Therapeutics Inc. (New York; STML) (lead)

5/17/13

$14.50

$19.60

$69.00

35%

Roth Capital Partners

Synta Pharmaceuticals Corp. (Lexington, Mass.; SNTA)

11/14/13

$3.75

$5.24

$60.38

40%

Roth Capital Partners

TG Therapeutics Inc. (New York; TGTX) (co-lead)

7/18/13

$6.15

$3.90

$35.10

-37%

Roth Capital Partners

Tonix Pharmaceuticals Holding Corp. (New York; TNXP) (lead)

8/9/13

$4.25

$10.31

$11.39

143%

Roth Capital Partners

Verastem Inc. (Cambridge, Mass.; VSTM)

7/18/13

$15.00

$11.40

$64.50

-24%

Roth Capital Partners

Xoma Corp. (Berkeley, Calif.; XOMA)

8/20/13

$3.62

$6.73

$31.50

86%

Sanford C. Bernstein

Portola Pharmaceuticals Inc. (South San Francisco; PTLA)

10/17/13

$23.75

$25.75

$105.90

8%

Sanford C. Bernstein

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (IPO)

5/22/13

$14.50

$25.75

$122.10

78%

Stifel, Nicolaus & Co.

Aerie Pharmaceuticals Inc. (Bedminster, N.J.; AERI) (IPO) (co-lead)

10/28/13

$10.00

$17.96

$77.20

80%

Stifel, Nicolaus & Co.

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (co-lead)

10/25/13

$16.50

$18.00

$37.95

9%

Stifel, Nicolaus & Co.

Bind Therapeutics Inc. (Cambridge, Mass.; BIND) (IPO)

9/20/13

$15.00

$15.09

$70.50

1%

Stifel, Nicolaus & Co.

Cempra Inc. (Chapel Hill, N.C.; CEMP) (co-lead)

6/14/13

$7.00

$12.39

$57.75

77%

Stifel, Nicolaus & Co.

Chemocentryx Inc. (Mountain View, Calif.; CCXI)

4/17/13

$12.00

$5.79

$60.00

-52%

Stifel, Nicolaus & Co.

Conatus Pharmaceuticals Inc. (San Diego; CNAT) (co-lead) (IPO)

7/25/13

$11.00

$6.45

$66.00

-41%

Stifel, Nicolaus & Co.

Discovery Laboratories Inc. (Warrington, Pa.; DSCO) (co-lead)

11/1/13

$2.00

$2.25

$50.00

13%

Stifel, Nicolaus & Co.

Discovery Laboratories Inc. (Warrington, Pa.; DSCO) (lead)

5/13/13

$1.50

$2.25

$14.25

50%

Stifel, Nicolaus & Co.

Durect Corp. (Cupertino, Calif.; DRRX) (lead)

11/8/13

$1.40

$1.73

$11.50

24%

Stifel, Nicolaus & Co.

Esperion Therapeutics Inc. (Plymouth, Mich.; ESPR) (IPO)

6/26/13

$14.00

$13.74

$80.50

-2%

Stifel, Nicolaus & Co.

Isis Pharmaceuticals Inc. (Carlsbad, Calif.; ISIS)

5/9/13

$19.00

$39.84

$182.70

110%

Stifel, Nicolaus & Co.

Keryx Biopharmaceuticals Inc. (New York; KERX)

1/31/13

$8.49

$12.95

$69.90

53%

Stifel, Nicolaus & Co.

Macrogenics Inc. (Rockville, Md.; MGNX) (IPO)

10/11/13

$16.00

$27.43

$92.00

71%

Stifel, Nicolaus & Co.

Mei Pharma Inc. (San Diego; MEIP) (co-lead)

10/28/13

$8.00

$8.01

$35.00

0%

Stifel, Nicolaus & Co.

Mei Pharma Inc. (San Diego; MEIP) (co-lead)

4/5/13

$7.50

$8.01

$15.20

7%

Stifel, Nicolaus & Co.

Newlink Genetics Corp. (Ames, Iowa; NLNK)

1/31/13

$11.40

$22.01

$52.44

93%

Stifel, Nicolaus & Co.

Omthera Pharmaceuticals Inc.2 (Princeton, N.J.; OMTH) (IPO)

4/12/13

$8.00

$12.70

$64.00

59%

Stifel, Nicolaus & Co.

Ophthotech Corp. (New York; OPHT) (IPO)

9/25/13

$22.00

$32.35

$192.28

47%

Stifel, Nicolaus & Co.

Progenics Pharmaceuticals Inc. (Tarrytown, N.Y.; PGNX)

6/21/13

$4.40

$5.33

$37.40

21%

Stifel, Nicolaus & Co.

Relypsa Inc. (Redwood City, Calif.; RLYP) (IPO)

11/15/13

$11.00

$25.00

$85.80

127%

Stifel, Nicolaus & Co.

Sophiris Bio Inc. (San Diego; SPHS) (IPO)

8/16/13

$5.00

$3.70

$65.00

-26%

Stifel, Nicolaus & Co.

Tekmira Pharmaceuticals Corp. (Vancouver, British Columbia; TKMR) (lead)

10/18/13

$8.00

$7.97

$35.00

0%

Stifel, Nicolaus & Co.

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH) (IPO)

3/20/13

$7.00

$13.52

$80.58

93%

Stifel, Nicolaus & Co.

Tetraphase Pharmaceuticals Inc. (Watertown, Mass; TTPH) (co-lead)

11/4/13

$10.00

$13.52

$49.00

35%

Stifel, Nicolaus & Co.

Zogenix Inc. (San Diego; ZGNX) (co-lead)

11/4/13

$2.25

$3.44

$68.85

53%

Summer Street Research

Rockwell Medical Inc. (Wixom, Mich.; RMTI)

5/15/13

$3.05

$10.44

$40.30

242%

Sunrise Securities Corp.

Alcobra Ltd. (Tel Aviv, Israel; ADHD) (IPO)

5/22/13

$8.00

$18.00

$25.00

125%

Suntrust Robinson

Acadia Pharmaceuticals Inc. (San Diego; ACAD)

5/15/13

$12.50

$24.99

$115.00

100%

Suntrust Robinson

Cempra Inc. (Chapel Hill, N.C.; CEMP)

6/14/13

$7.00

$12.39

$57.75

77%

Suntrust Robinson

Conatus Pharmaceuticals Inc. (San Diego; CNAT) (IPO)

7/25/13

$11.00

$6.45

$66.00

-41%

Trout Capital

Prosensa Holding BV (Leiden, the Netherlands; RNA) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

UBS Investment Bank

Ariad Pharmaceuticals Inc. (Cambridge, Mass.; ARIA)

1/24/13

$19.60

$6.82

$323.40

-65%

UBS Investment Bank

Intermune Inc. (Brisbane, Calif.; ITMN)

11/6/13

$13.00

$14.73

$84.50

13%

Wedbush Pacgrow Life Sci.

Anacor Pharmaceuticals Inc. (Palo Alto, Calif.; ANAC)

4/26/13

$6.39

$16.78

$23.00

163%

Wedbush Pacgrow Life Sci.

Bluebird Bio Inc. (Cambridge, Mass.; BLUE) (IPO)

6/19/13

$17.00

$20.98

$116.11

23%

Wedbush Pacgrow Life Sci.

Celldex Therapeutics Inc. (Hampton, N.J.; CLDX)

12/5/13

$24.50

$24.21

$191.40

-1%

Wedbush Pacgrow Life Sci.

Celldex Therapeutics Inc. (Needham, Mass.; CLDX)

2/6/13

$7.50

$24.21

$103.50

223%

Wedbush Pacgrow Life Sci.

Cerus Corp. (Concord, Calif.; CERS)

3/14/13

$4.20

$6.45

$35.00

54%

Wedbush Pacgrow Life Sci.

Epizyme Inc. (Cambridge, Mass.; EPZM) (IPO)

5/31/13

$15.00

$20.80

$88.70

39%

Wedbush Pacgrow Life Sci.

Fate Therapeutics Inc. (San Diego; FATE) (IPO)

10/1/13

$6.00

$6.28

$46.20

5%

Wedbush Pacgrow Life Sci.

Fibrocell Science Inc. (Exton, Pa.; FCSC)

9/26/13

$4.10

$4.06

$50.43

-1%

Wedbush Pacgrow Life Sci.

Intercept Pharmaceuticals Inc. (New York; ICPT)

6/19/13

$33.01

$68.28

$65.69

107%

Wedbush Pacgrow Life Sci.

Macrogenics Inc. (Rockville, Md.; MGNX) (IPO)

10/11/13

$16.00

$27.43

$92.00

71%

Wedbush Pacgrow Life Sci.

Mei Pharma Inc. (San Diego; MEIP)

10/28/13

$8.00

$8.01

$35.00

0%

Wedbush Pacgrow Life Sci.

Novavax Inc. (Rockville, Md.; NVAX)

9/24/13

$3.14

$5.12

$99.85

63%

Wedbush Pacgrow Life Sci.

Oncolytics Biotech Inc. (Calgary, Alberta; ONCY) (co-lead)

2/21/13

$4.00

$1.55

$32.00

-61%

Wedbush Pacgrow Life Sci.

Prosensa Holding BV (Leiden, the Netherlands; RNA) (IPO)

6/28/13

$13.00

$4.67

$89.70

-64%

Wedbush Pacgrow Life Sci.

Prothena Corp. plc (Dublin; PRTA)

10/13/13

$22.00

$26.52

$77.00

21%

Wedbush Pacgrow Life Sci.

PTC Therapeutics Inc. (South Plainfield, N.J.; PTCT) (IPO)

6/20/13

$15.00

$16.97

$144.48

13%

Wedbush Pacgrow Life Sci.

Receptos Inc. (San Diego; RCPT) (IPO)

5/9/13

$14.00

$28.99

$72.80

107%

Wedbush Pacgrow Life Sci.

Regado Biosciences Inc. (Basking Ridge, N.J.; RGDO) (IPO)

8/22/13

$4.00

$4.77

$46.68

19%

Wedbush Pacgrow Life Sci.

Regulus Therapeutics Inc. (La Jolla, Calif.; RGLS)

7/17/13

$9.50

$7.39

$49.20

-22%

Wedbush Pacgrow Life Sci.

Relypsa Inc. (Redwood City, Calif.; RLYP) (IPO)

11/15/13

$11.00

$25.00

$85.80

127%

Wedbush Pacgrow Life Sci.

Xencor Inc. (Redwood City, Calif.; XNCR) (IPO) (co-lead)

12/3/13

$5.50

$9.14

$80.30

66%

Wells Fargo Securities

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN)

3/1/13

$8.40

$3.32

$141.96

-60%

Wells Fargo Securities

Biocryst Pharmaceuticals Inc. (Research Triangle Park, N.C.; BCRX) (co-lead)

8/2/13

$4.40

$7.60

$20.20

73%

Wells Fargo Securities

Five Prime Therapeutics Inc. (South San Francisco; FPRX) (co-lead) (IPO)

9/18/13

$13.00

$16.79

$71.80

29%

Wells Fargo Securities

Insys Therapeutics Inc. (Phoenix; INSY) (co-lead) (IPO)

5/2/13

$8.00

$38.71

$32.00

384%

Wells Fargo Securities

Intermune Inc. (Brisbane, Calif.; ITMN)

11/6/13

$13.00

$14.73

$84.50

13%

Wells Fargo Securities

Intermune Inc. (Brisbane, Calif.; ITMN)

1/16/13

$9.90

$14.73

$133.65

49%

Wells Fargo Securities

Zogenix Inc. (San Diego; ZGNX) (co-lead)

11/4/13

$2.25

$3.44

$68.85

53%

William Blair & Co.

Biodel Inc. (Danbury, Conn.; BIOD) (lead)

6/20/13

$4.35

$2.28

$19.49

-48%

William Blair & Co.

Chimerix Inc. (Research Triangle Park, N.C.; CMRX) (IPO)

4/11/13

$14.00

$15.11

$102.50

8%

William Blair & Co.

Dynavax Technologies Corp. (Berkeley, Calif.; DVAX)

10/25/13

$1.08

$1.96

$132.20

82%

William Blair & Co.

Intermune Inc. (Brisbane, Calif.; ITMN)

1/16/13

$9.90

$14.73

$133.65

49%

William Blair & Co.

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO)

9/26/13

$4.00

$4.42

$30.00

11%

William Blair & Co.

Kalobios Pharmaceuticals Inc. (South San Francisco; KBIO) (IPO)

1/31/13

$8.00

$4.42

$70.00

-45%

William Blair & Co.

Portola Pharmaceuticals Inc. (South San Francisco; PTLA)

10/17/13

$23.75

$25.75

$105.90

8%

William Blair & Co.

Portola Pharmaceuticals Inc. (South San Francisco; PTLA) (IPO)

5/22/13

$14.50

$25.75

$122.10

78%

William Blair & Co.

Ventrus Biosciences Inc. (New York; VTUS) (lead)

2/4/13

$2.50

$3.82

$22.20

53%

William Blair & Co.

Zogenix Inc. (San Diego; ZGNX)

11/4/13

$2.25

$3.44

$68.85

53%


Notes

*The financings in this chart are for public offerings in the U.S. only. They do not include offerings of convertible senior notes or at-the-market offerings. They do not include public offerings in which there were no underwriters. The data were compiled primarily from BioWorld Insight’s monthly financing charts covering the period from Jan. 1 to Dec. 31 , 2013. The gross proceed totals listed reflect only those shares sold by companies. They include money raised through overallotment options, when disclosed.

** All prices are in U.S. dollars.

Offering price per share is adjusted to reflect any post-offering splits.

Unless otherwise noted, shares are traded on the Nasdaq exchange. NYSE = New York Stock Exchange. OTCQB = Over-the-Counter; AMEX = American Stock Exchange. IPO = Initial Public Offering

1 Oxygen Biotherapeutics offered 5,369 units at $1 ,000 each, consisting of 2.75M shares at $1 .95 per share.

2 Omthera’s Dec. 31 , 2013, stock price listed is the price, $12.70 per share, in which Astrazeneca plc agreed to acquire the company.

3 Aastrom’s offering price listed accounts for a 1-for-20 stock split that occurred on Oct. 16, 2013.

4 Neostem’s offering price listed accounts for a 1-for-10 stock split that occurred on July 16, 2013.

5 Oculus’ offering price listed accounts for a 1-for-7 stock split that occurred on April 1, 2013.

6 Anthera’s offering price listed accounts for a 1-for-8 stock split that occurred on July 15, 2013.

7 Cubist Pharmaceuticals Inc. acquired Trius in September 2013. The final stock price occurred on Sept. 11, 2013.

8 Onyx’s Dec. 31, 2013, stock price listed is the price, $125 per share, for which Amgen Inc. acquired the company in August 2013.